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תגית: Design Review

ולידציה – 3 Validation case study – part

Posted on by אביב צברי

ולידציה – 3 Validation case study – part

 This article was written by Iian Shaya, validation,automation and control expert

אילן שעיה Ilan Shaya
Ilan Shaya CEO , control and automation specialist and designer

Documentation for IQ and OQ – to be checked at PDI/FAT

Welding reports

Surfaces finishing test reports

PDI and FAT results

As-built drawings, 3 sets in nominated project language, plus 1 set in English

As-installed versions of all documentation submitted for design review

Back-up software on diskette/CD-ROM, as appropriate, ready for re-installment

Machine configuration/start up, set-up and commissioning data, including tabulation of all change parts and identifications

Full machine parts list

Complete documentation (protocols and method statements) required for equipment DQ, calibration, IQ and OQ specified for manual and automatic operations

Calibration certificates for all required instruments to NIST

Specification for all parts manufactured by sub-contractors

Full identification of all parts according to the P&ID, including valves, regulators, instruments, pipes, media and flow direction arrows

Tags for electrical and pneumatic wiring

Documentation to ensure qualification in compliance with FDA and EMEA, as outlined above

DQ Protocols Including PC/PLC

Approval

Statement of purpose

System description

Traceability matrix

IQ Protocols Including PC/PLC

Approval

Statement of purpose

System description

Specifications

Materials in product contact

Engineering drawings

Subsystem inspection

Components

Piping

Valves

Instrumentation and calibrations

PC/PLC requirement definition

Software development documentation

Manual / technical literature

Test equipment data sheet

Component data sheets

Utility requirements

Exceptional conditions, if required

Summary

OQ Protocols Including PC/PLC

Statement of purpose

System description

Manual and automatic control over all modules through HMI

PC/PLC validation protocols

Step-by-step checking of schedule of system operation – SSO

Alarm and message reaction

HMI synoptic screen vs. P&ID

System operation tests

Operation tests for HMI to ensure compliance with 21 CFR part 11

Application software certification

HW documentation

SW code

SW components data sheets

HW components data sheets

PLC configuration

Graph printout

Synoptic screen list and printout

Operation screen list and printout

Parameters list screen

Messages and alarms list, and printout

HW inspections

SW inspections and application

Approved schematic description

Ladder diagram validation

PLC capabilities

PLC accuracy

SW development documentation

List of control devices

Exceptional conditions

Reports – verification of authorization inspection

PQ Protocols Including PC/PLC

Statement of purpose

Analysis procedures

Staff instruction

Plan for sampling

Criteria for acceptance

 This article was written by Iian Shaya, validation,automation and control expert

ולידציה – Validation case study – part 2

Posted on by אביב צברי

ולידציה – Validation case study – part 2

 This article was written by Iian Shaya, validation,automation and control expert

Validation Requirements

Documentation for Initial Tender

Project schedule and milestones design and construction detail

Project quality plan

Supplier’s local subsidiary/agent

Supplier’s documentation that the system / configurable software versions are released to the market and are FDA/EMEA compliant

Compliance to the 21 CFR Part 11 operational requirements – the contractor should ensure covering of all the requirements described below

Contractor to state the system/product status and implementation planned for each requirement – User's approval pre-delivery

Documentation for Design Review

PID for the system

Electrical and pneumatic schematics

:Installation data

General arrangement drawings

Floor loading

Utility requirements

Details of electronic records and approvals that may be subject to regulatory controls under CFR Title 21 part 11

Instrumentation documentation

:Main components specification

Equipment

Instrumentation

Valves

Piping

Control system

Pipe welding documentation

General installation book

Procedures

User guide

Security

Preventative maintenance + spare parts list

Operation procedure

Pressure test procedure

Leak test procedure

Passivation procedure

Calibration

:Functional Design Specifications for

Complete manufacturing system

Software – SW and hardware –HW

Functional Design Specifications

System Detail Design Specifications for HW and SW.

SW source code, with comments, for customized SW

SW complete version history

HMI alarm list, message list and graphical displays

I/O list

:List of materials

Product contact materials

Potential product contact lubricants

Welding procedures for product direct and indirect contact parts

Pre-delivery Inspection and Factory Acceptance Test (FAT) protocols

Steel certificates and gasket certificates

Documentation Prior to FAT or Pre-Delivery Inspection – PDI

:Progress visit report which will include

Mechanical and technical development

Automation and SW development

:Supplier’s factory test results for

Unit tests – The test protocols shall be traced to low level design document and will be approved by the user prior to execution. The approval of the report shall be performed by representatives of the user's validation team, IT QA.

Automation and SW development

:Integration Tests  – Simulation Testing

Approved PDI and FAT protocols

Commissioning

MCCR

Purpose

Scope

Responsibility

Execution instructions

System scope

System description

Drawing verification

Equipment verification

Valve verification

Instrument installation and calibration

Utility verification

Documentations verification

Piping Verification

Sample Point Verification

Safety, health and environment verification

Slopes verification (if relevant)

Electrical and communication activities

Pump installation verification, if relevant

Heat exchanger installation verification, if relevant

Air break verification, if relevant

Dead leg verification, if relevant

CE

Purpose

Scope

Responsibility

Execution instructions

System scope

System description

System startup

Equipment verification

Main equipment operation checks

System FDS (SSO) verification

System performance testing

 This article was written by Iian Shaya, validation,automation and control expert

ולידציה – DQ – Design Review

Posted on by אביב צברי

 ולידציה – DQ – Design Qualification / Design Review

DQ  – Design Qualification is for Design Review by verifying that the system has been designed as specified in the URS (User Requirements Specification), FDS (Functional Design Specification), and relevant equipment specifications satisfying all GMP requirements. The Process User Requirements in the URS have been identified by the Quality Risk Assessment. Since the Quality Risk Assessment is an iterative process, it may be performed again, whenever necessary, during the DQ and subsequent lifecycle qualifications.  For  hardware and software of the control system, verification data will be collected to prove that the system has been designed in accordance with the URS and FDS including the requirements of 21 CFR Part 11. As DQ is the final step to formally review and document the proper design of the system, the protocol must enable the reviewers to verify that all quality-critical attributes and essential technical attributes of the system have been incorporated in the design. When the DQ report is approved, the system is ready for fabrication and construction.

DQ PROTOCOLS
PROCESS EQUIPMENT AND SYSTEMS
Media Preparation and Hold Tanks
Buffer Preparation and Hold Tanks
Process Tanks
Reactors – Organic Synthesis
Bioreactors
Evaporator Systems
Distillation Tower Systems

CLEAN UTILITY SYSTEMS
USP Purified Water Storage and Distribution Systems
WFI Storage and Distribution Systems
Clean Steam Generation and Distribution Systems
Process Air Systems
Nitrogen Gas Systems

SUPPORT SYSTEMS
CIP Systems
Biowaste Kill Systems – Continuous
Biowaste Kill Systems – Batch
Autoclaves

HVAC SYSTEMS AND CLEANROOMS
HVAC Systems
Cleanrooms – Aseptic
Air Locks – Gowning

LABORATORY EQUIPMENT
Incubators
CO2 Incubators
Water Bath Incubators
Ultra-Low Temperature Freezers
Refrigerators